Structural Genomics (WP5.1)

Please note:  EADGENE Partners can access more information by logging in to the Intranet (click here). The scientific focus of this workpackage was on the improvement of genome maps and annotation of the genes in farm animals (chicken, pigs, cattle, salmon). New genomic information has been developed and implemented in accessible databases resulting in up to date comparative maps of farm animals. This information was then used to further improve the annotation of genes and mapping of regulatory elements such as promoters and miRNA’s. In addition, a common trait ontology has been developed focusing on the immune system and host components involved in host-pathogen interactions.

WP Objectives:

Improve the annotation of the genomes for the major farm animals (chicken, pig, cattle, sheep, and fish) 
Identification of regulatory elements by a comparison of co-regulated genes
Analysis of miRNA genes and their (potential) targets
Improve ontology relevant for host-pathogen interactions and immunology
Global analysis of genetic variation (CNV, SNPs) in the genome of farm animals.

WP Achievements:  

• Maps and gene annotation of animal and microbial genomes improved
• Establishment of comparative genome maps and miRNA database
• Identification of candidate genes and (large scale) SNP discoveries
• Genotyping using whole genome and targeted approaches 
 

WP Leader:  Martien Groenen (WUR, NL)

Partners involved:

• Institute National de la Recherche Agronomique (INRA), France
• Wageningen University (WUR), NL
• Animal Sciene Group Lelystad, (ASG-Lelystad), NL
• Institute for Animal Health (IAH), UK
• Roslin Institute and R(D)SVS, University of Edinburgh (UEDIN), UK
• University of Aarhus Faculty of Agricultural Sciences (formerly DIAS), Denmark
• Liege University, (FMV-ULG) Belgium
• Ljubljana University, Slovenia
• Norwegian School of Veterinary Science (NSVS), Norway
• Parco Tecnologico Padano (PTP), Italy